OverviewKL GradesAI WorkflowExplainabilityPerformance
AI-assisted musculoskeletal imaging

Objective knee OA grading.
From one X-ray.

OrthoGrade AI combines eight complementary deep-learning networks to estimate Kellgren–Lawrence severity from knee radiographs—then reveals the joint regions that influenced the decision.

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0Knee X-rays
0Model families
0KL severity grades
0Cross-validation folds
LIVE RADIOGRAPH REVIEW
SYSTEM READY
Knee X-ray for KL grade 0
Predicted KL grade 0
Ensemble confidence
91%
THE CLINICAL SCALE

Five stages. One continuous severity story.

The Kellgren–Lawrence scale progresses from a radiographically normal joint to severe osteoarthritis. Select a grade to inspect the characteristic pattern and watch the dataset spectrum respond.

Representative radiograph
Selected KL grade knee X-ray
Joint space
Marginal bone
KL GRADE0

No radiographic osteoarthritis

Normal-appearing joint space without definite osteophytes or structural narrowing.

Joint-space narrowingNone
Osteophyte evidenceNone
Structural deformityNone
Important The grade is a radiographic severity category, not a standalone diagnosis. Symptoms and clinical context still matter.
ANIMATED DATASET VIEW

Severity spectrum scanner

Grade 0 active
Kellgren-Lawrence grade spectrum from grade 0 to grade 4
WHAT IS HAPPENING

Eight specialists vote on one answer.

Instead of trusting a single neural network, the system trains a portfolio of architectures at image sizes that suit each model. During inference, original and horizontally flipped views are combined through mixed hard-and-soft voting.

01
XR

Normalize the radiograph

Each knee X-ray is prepared and resized into several model-specific resolutions.

02

Run diverse CNNs

Eight pretrained model families learn complementary texture, shape and joint-space cues.

03

Test-time augmentation

The original image and a horizontal flip are evaluated to make predictions more stable.

04
Σ

Mixed ensemble vote

Hard class votes and soft probabilities are fused into the final grade estimate.

05

Explain the focus

Grad-CAM highlights the image regions contributing most strongly to the prediction.

MODEL ARCHITECTURE

Model-specific image sizing

Different network families receive images at resolutions selected for their own representational strengths, rather than forcing every model to use one common size.

DenseNet-161EfficientNet-B5EfficientNet-V2-SRegNet-Y-8GFResNet-101ResNeXt-50Wide ResNet-50ShuffleNet-V2
Ensemble architecture diagram
EXPLAINABLE AI

See where the ensemble is looking.

Grad-CAM heatmaps provide a visual check that the network is attending to clinically meaningful regions—especially the tibiofemoral joint space and areas associated with osteophyte formation.

ORIGINAL INPUT — GRADES 0 TO 4Grad-CAM inspection
Original knee X-rays across KL grades
01

Joint-space narrowing

The gap between femur and tibia becomes progressively reduced as cartilage loss advances.

02

Osteophyte formation

Marginal bony growths around the joint are a defining radiographic cue in KL grading.

03

Subchondral change

Increased density and structural remodeling may appear with more advanced disease.

04

Bone-end deformity

Severe grades can show marked contour change and loss of normal joint architecture.

REPORTED RESEARCH PERFORMANCE

Consistency through diversity.

The ensemble was evaluated on a held-out test set after stratified five-fold cross-validation. Results below reflect the reported experimental study and are not a claim of clinical deployment performance.

Overall accuracy76.93%
Ensemble
F1 score0.7665

Balance between precision and recall across five ordered classes.

Study images8,260

Posterior–anterior fixed-flexion knee radiographs across KL grades 0–4.

Independent test set1,656

Held apart from cross-validation and model training.

GENERALIZATION STRATEGY

Stratified five-fold validation

The 6,604 training-and-validation images are divided into five class-balanced folds. Four folds train the models while one validates them, rotating until every fold has served as validation.

Training foldsValidation fold
Run 1
Run 2
Run 3
Run 4
Run 5
AI
INSTRUMENT-READY STORY

From acquisition to structured severity insight.

For a demonstration environment, the workflow can sit beside a digital radiography system: receive a knee image, estimate the KL grade, expose the attention map, and produce a standardized summary for clinician review.

Automatic image intakeFive-class probability outputAttention-map reviewPDF-ready summary
Research presentation notice

This website demonstrates a published experimental AI workflow. It is not a medical device and must not be used as the sole basis for diagnosis, treatment or patient management.

ORTHOPAEDIC IMAGING INTELLIGENCE

Make every knee X-ray easier to interpret, compare and communicate.

Objective grading. Visible evidence. A presentation built for clinical, laboratory and instrument stakeholders.

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